Research
Our overarching goals are to discover proteo-genomic molecular drivers of cancer initiation and progression, that may be used as targets for cancer detection and therapy.
We are studying human and murine pre-cancer and cancer tissue of digestive organs, leveraging spatial transcriptomics, genomics, proteomic, and digital computational tools to establish in-depth disease multidimensional maps.
Our recent publication in Cellular and Molecular Gastroenterology and Hepatology (Sun J. et al. 2024) demonstrated that oncogenic KRASG12D synergizes with p16-deletion resulting in higher-grades of glandular dysplasia, supporting a functional role of p16 and KRAS in the progression of Barrett’s esophagus like lesions to dysplasia.
